Experimental model of type 2 diabetes induced by fat diet consumption and low dose of streptozotocin in C57BL/6J mice

نویسندگان

  • Mariana de Freitas Moreira
  • Natalia do Vale Canabrava
  • Sandra Machado Lira
  • Tatiane Rodrigues Oliveira
  • José Ytalo Gomes da Silva
  • Marcelo Oliveira Holanda
  • Carla Laíne Silva Lima
  • Julianne do Nascimento Sales
  • Arnaldo Solheiro Bezerra
  • Bruno Bezerra da Silva
  • Erlândia Alves Magalhães Queiroz
  • Paula Alves Salmito Rodrigues
  • Raquel Teixeira Terceiro Paim
  • Lia Magalhães de Almeida
  • Maria Izabel Florindo Guedes
چکیده

Experimental model of type 2 diabetes induced by fat diet consumption and low dose of streptozotocin in C57BL/6J mice Mariana de Freitas Moreira, Natalia do Vale Canabrava, Sandra Machado Lira, Tatiane Rodrigues Oliveira, José Ytalo Gomes da Silva, Marcelo Oliveira Holanda, Carla Laíne Silva Lima, Julianne do Nascimento Sales, Arnaldo Solheiro Bezerra, Bruno Bezerra da Silva, Erlândia Alves Magalhães Queiroz, Paula Alves Salmito Rodrigues, Raquel Teixeira Terceiro Paim, Lia Magalhães de Almeida, Maria Izabel Florindo Guedes

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A comparative study of the antidiabetic effect of two training protocols on miR-133aand Runx2 in high-fat diet and streptozotocin-induced diabetic: an experimental study

Background: Type 2 diabetes (T2D) in the elderly is an epidemic that has major impact on global health. Thus this experimental study aimed to compare the response of microRNA-133a (miR-133a) in different tissues and of Runt-related transcription factor 2 (Runx2) in bone marrow tissue following resistance and endurance training in old rats with high-fat diet and streptozotocin (HFD/STZ)-induced ...

متن کامل

Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat Diet

Introduction: Diabetes is a metabolic disease, which is directly correlated with increased physical disabilities and muscle tissue damage. The present study aimed to investigate the anti-apoptotic effects of interval and continued training and crocin on diabetic rats. Methods: In this study, 49 adult rats aged eight weeks with diabetes inducaed by a high-fat di...

متن کامل

Momordica cymbalaria fruit extract attenuates high-fat diet-induced obesity and diabetes in C57BL/6 mice

Objective(s): The present study was aimed to evaluate the effect of methanolic fruit extract of Momordica cymbalaria (MeMC) against high-fat diet-induced obesity and diabetes in C57BL/7 mice.Materials and Methods: In the present study, six weeks old male C57BL/6 mice were divided into four groups. G-1 and G-2 served as lean control and HFD control, G-3 and G-4 received MeMC 25 and 50 mg/kg, BW ...

متن کامل

Effect of Aerobic Exercise Training on Left Ventricular Apoptotic and Antioxidant Indices in High Fat Diet and Streptozotocin-induced Type 2 Diabetic Rat Model

Introduction: Exercise training has been suggested as a potential non-pharmacological strategy to prevent cardiovascular injuries. However, the role of exercise is controversial in preventing the progression of injuries caused by diabetic cardiomyopathy or their repairing. Therefore, this study aimed to evaluate the effect of aerobic exercise training on left ventricular apoptotic and antioxida...

متن کامل

A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes

Type 2 diabetes mellitus (T2DM) represents a complex clinical scenario of altered energy metabolism and increased fracture incidence. The C57BL/6 mouse model of diet-induced obesity has been used to study the mechanisms by which altered glucose homeostasis affects bone mass and quality, but genetic variations in substrains of C57BL/6 may have confounded data interpretation. This study investiga...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2015